Effects of anti-inflammatory, anticoagulant and vasoactive compounds on tail bleeding time, whole blood coagulation time and platelet retention by glass beads in rats.

摘要: Abstract In rats, the tail bleeding time, whole blood clotting time and platelet retention by glass beads were evaluated as a potential test battery for large-scale screening of platelet-active anticoagulant compounds. The prostaglandin-biosynthesis inhibitors suprofen, phenylbutazone, indomethacin acetylsalicylic acid pyrimidino-pyrimidine compound VK774 all prolonged to some extent time. Only reduced retention. None compounds affected times. Warfarin sodium heparin times without effect on They produced moderate but significant prolongation conclusion proposed may be useful potent drugs.