Future therapies targeted towards eliminating Candida biofilms and associated infections.

摘要: ABSTRACTIntroduction: Candida species are common human commensals and cause either superficial or invasive opportunistic infections. The biofilm form of candida as opposed to its suspended, planktonic form, is predominantly associated with these Alternative adjunctive therapies urgently needed manage infections the currently available short arsenal antifungal drugs has been compromised due their systemic toxicity, cross-reactivity other drugs, above all, by emergence drug-resistant irrational drug use.Areas covered: Combination anti-Candida therapies, lock therapy, denture cleansers, mouth rinses have all proposed alternatives for disrupting candidal biofilms on different substrates. Other suggested approaches management candidiasis include use natural compounds, such probiotics, plants extracts oils, quorum sensing molecules, antibodies vaccines, cytoki...