Serum Metabolomics of Slow vs. Rapid Motor Progression Parkinson’s Disease: a Pilot Study

摘要: Progression of Parkinson’s disease (PD) is highly variable, indicating that differences between slow and rapid progression forms could provide valuable information for improved early detection management. Unfortunately, this represents a complex problem due to the heterogeneous nature humans in regards demographic characteristics, genetics, diet, environmental exposures health behaviors. In pilot study, we employed high resolution mass spectrometry-based metabolic profiling investigate signatures versus rapidly progressing PD present human serum. Archival serum samples from patients obtained within 3 years onset were analyzed via dual chromatography-high spectrometry, with data extraction by xMSanalyzer used predict or motor these during follow-up. Statistical analyses, such as false discovery rate analysis partial least squares discriminant analysis, yielded list statistically significant features further investigation revealed potential biomarkers. particular, N8-acetyl spermidine was found be significantly elevated progressors compared both control subjects progressors. Our exploratory indicate fast phenotype can distinguished using altered polyamine metabolism may predictive marker PD.