Disaccharides Impact the Lateral Organization of Lipid Membranes

摘要: Disaccharides are well-known for their membrane protective ability. Interaction between sugars and multicomponent membranes, however, remains largely unexplored. Here, we combine molecular dynamics simulations fluorescence microscopy to study the effect of mono- disaccharides on membranes that phase separate into Lo Ld domains. We find nonreducing disaccharides, sucrose trehalose, strongly destabilize separation leading uniformly mixed as opposed monosaccharides reducing disaccharides. To unveil driving force this process, were performed in which sugar linkage was artificially modified. The availability accessible interfacial binding sites can accommodate is key strong impact lateral organization. These exclusive interactions may rationalize why organisms such yeasts, tardigrades, nematodes, bacteria, plants accumulat...