HLA-DPβ and susceptibility to multiple sclerosis: An analysis of caucasoid and Japanese patient populations
作者： Ann B Begovich , Rhea C Helmuth , Jorge R Oksenberg , Koichiro Sakai , Takeshi Tabira
DOI: 10.1016/0198-8859(90)90031-J
关键词:
摘要: Nonradioactive sequence-specific oligonucleotide (SSO) probes specific for the HLA-DP beta locus have been used in a simple dot-blot assay to DP beta-type samples amplified by polymerase chain reaction (pcr) from Caucasoid (n = 24) and Japanese 23) patients with multiple sclerosis (ms) as well ethnically matched controls. In contrast previous reports, no allele was found be increased either patient population. However, results do show dramatic difference frequencies between two control populations, further emphasizing need controls studies of HLA disease.
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