Lipids, lipophilic drugs, and oral drug delivery-some emerging concepts.

作者: William N. Charman

DOI: 10.1002/1520-6017(200008)89:8<967::AID-JPS1>3.0.CO;2-R

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摘要: … , the lipid digestion products must dissociate from the micelle … exists in equilibrium with the micellar phase,32 with further … a decrease in the micellar solubilization capacity and hence an …

参考文章(111)
Susan A. Charman, William N. Charman, Mark C. Rogge, Terry D. Wilson, Frank J. Dutko, Colin W. Pouton, Self-emulsifying drug delivery systems: formulation and biopharmaceutic evaluation of an investigational lipophilic compound. Pharmaceutical Research. ,vol. 9, pp. 87- 93 ,(1992) , 10.1023/A:1018987928936
Jay M. Dintaman, Jeffrey A. Silverman, Inhibition of P-Glycoprotein by D-α-Tocopheryl Polyethylene Glycol 1000 Succinate (TPGS) Pharmaceutical Research. ,vol. 16, pp. 1550- 1556 ,(1999) , 10.1023/A:1015000503629
Christopher J. H. Porter, William N. Charman, Model systems for intestinal lymphatic transport studies. Pharmaceutical biotechnology. ,vol. 8, pp. 85- 102 ,(1996) , 10.1007/978-1-4899-1863-5_6
Andrea Soldner, Uwe Christians, Miki Susanto, Vincent J. Wacher, Jeffrey A. Silverman, Leslie Z. Benet, Grapefruit juice activates P-glycoprotein-mediated drug transport. Pharmaceutical Research. ,vol. 16, pp. 478- 485 ,(1999) , 10.1023/A:1011902625609
Kiyomi Ito, Hiroyuki Kusuhara, Yuichi Sugiyama, Effects of intestinal CYP3A4 and P-glycoprotein on oral drug absorption--theoretical approach. Pharmaceutical Research. ,vol. 16, pp. 225- 231 ,(1999) , 10.1023/A:1018872207437
Viness Pillay, Reza Fassihi, A New Method for Dissolution Studies of Lipid-Filled Capsules Employing Nifedipine as a Model Drug Pharmaceutical Research. ,vol. 16, pp. 333- 337 ,(1999) , 10.1023/A:1011959914706
Bryan D. Tarr, Samuel H. Yalkowsky, Enhanced intestinal absorption of cyclosporine in rats through the reduction of emulsion droplet size. Pharmaceutical Research. ,vol. 6, pp. 40- 43 ,(1989) , 10.1023/A:1015843517762
Lise A. Eliot, Robert T. Foster, Fakhreddin Jamali, Effects of hyperlipidemia on the pharmacokinetics of nifedipine in the rat. Pharmaceutical Research. ,vol. 16, pp. 309- 313 ,(1999) , 10.1023/A:1018896912889
Dirk L. Teagarden, Bradley D. Anderson, William J. Petre, Determination of the pH-dependent phase distribution of prostaglandin E1 in a lipid emulsion by ultrafiltration Pharmaceutical Research. ,vol. 5, pp. 482- 487 ,(1988) , 10.1023/A:1015961122982
Ulrike Wetterich, Hildegard Spahn‐Langguth, Ernst Mutschler, Bernd Terhaag, Wolfgang Rösch, Peter Langguth, Evidence for intestinal secretion as an additional clearance pathway of talinolol enantiomers: concentration- and dose-dependent absorption in vitro and in vivo. Pharmaceutical Research. ,vol. 13, pp. 514- 522 ,(1996) , 10.1023/A:1016029601311