Maternal hypoxia activates endovascular trophoblast cell invasion.

摘要: Oxygen is a critical regulator of placentation. Early placental development occurs in predominantly low oxygen environment and is, at least partially, under the control hypoxia signaling pathways. In present study, vivo hypobaric was used as an experimental tool to delineate hypoxia-sensitive events during Pregnant rats were exposed equivalent 11% between days 6.5 13.5 gestation. Pair-fed pregnant animals ambient conditions included group. Uterine mesometrial blood vessels hypoxia-exposed greatly expanded some contained large cuboidal cells that positive for cytokeratin other markers characteristic invasive trophoblast cells. Unlike later gestation, route cell invasion restricted endovascular, with no interstitial observed. Hypoxia-activated endovascular required exposure from gestation day 8.5 9.5. Activation lineage also associated enlargement junctional zone chorioallantoic placenta, source progenitors. summary, maternal early stages placentation activates promotes uterine vascular remodeling.