HPA axis hyperactivity and cardiovascular mortality in mood disorder inpatients

摘要: Depression is associated with an increased risk of cardiovascular disease (CVD), coronary heart (CHD) and cardiac death. Dysregulation the hypothalamic-pituitary-adrenal (HPA) axis function frequent in major depression hypercortisolemia may be a mediating factor these relationships. The aim this study was to assess HPA measured dexamethasone suppression test (DST) relation CVD CHD mortality cohort 382 inpatients mood disorder admitted department Psychiatry at Karolinska University Hospital between 1980 2000. Death certificates ascertained that 75 patients had died 30 during mean follow-up 18 years. DST non-suppression higher baseline serum cortisol predicted In male disorder, non-suppressor status significantly death but not depressed female mortality. Baseline post-dexamethasone levels 4:00 p.m. showed trend CVD/CHD victims. Effect aging on functioning shown deaths. dysregulation indicating HPA-axis hyperactivity long term for