Hypercortisolemic depression is associated with the metabolic syndrome in late-life

摘要: Summary Introduction Depression has been hypothesized to be associated with metabolic abnormalities which increase the risk of cardiovascular disease (CVD) and diabetes. Such a link could due increased HPA-axis activity. This study investigates cross-sectional relationship between depression, urinary cortisol syndrome in an older population. Methods Data are from 867 participants InChianti Study, aged ⩾65 years. Depressive symptoms were assessed using CES-D scale; levels determined 24-h urine samples. Metabolic was defined as three or more following: abdominal obesity, high triglycerides, low HDL cholesterol, blood pressure, fasting glucose. Results Clinically relevant depressed mood (CES-D⩾20) present 20.6% sample, 24.5% had syndrome. After adjustment for sociodemographics health indicators, depression score (per SD increase: OR=1.20, 95% CI=1.02–1.41) level OR=1.23, CI=1.01–1.51) significantly presence There was, however, significant interaction ( p = 0.003 ) probability having The odds persons both excretion highest tertile 1.84 (95% CI=1.02–3.34) compared neither condition. Discussion suggests synergistic Hypercortisolemic may constitute specific group