Automated analysis of FISH-stained HER2/neu samples with Metafer.

作者: Christian Schunck , Eiman Mohammad

DOI: 10.1007/978-1-61779-055-3_6

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摘要: The HER2/neu gene (also known as ERBB2) is located on chromosome 17 (q11.2-q12) and encodes a glycoprotein to be member of the epidermal growth factor receptor family. Clinically, determination its amplification status utmost importance, 10-35% invasive human breast carcinomas come along with overexpression, treatment has adjusted accordingly. Here method analyze HER2 FISH samples digital microscopy, using slide scanning -platform Metafer PV (MetaSystems, Altlussheim, Germany), presented. system for automation assay analysis hybridized Abbott(™) PathVysion(®) probe kit.

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