A specific spectral signature of serum and plasma-derived extracellular vesicles for cancer screening
作者： Christoph Krafft , Konrad Wilhelm , Anna Eremin , Sigrun Nestel , Nikolas von Bubnoff
DOI: 10.1016/J.NANO.2016.11.016
关键词:
摘要: In cancer, extracellular vesicles (EV) contribute to tumor progression by regulating local and systemic effects. Being released into body fluids, EV may be used in nanomedicine as a valuable source for diagnostic biomarkers. this work, infrared Raman spectroscopy were comprehensive comparative analysis of cancer versus non-cancer patient screening. Two different fractions enriched exosomes microvesicles isolated differential centrifugation from serum plasma patients healthy donor. The then subjected drop-coating deposition drying on calcium fluoride substrates. Reduction alpha-helix-rich proteins enhancement beta-sheet-rich cancer-specific blood signature was determined, subsequently feature applied pilot study aiming detect prostate test cohort with high-grade carcinoma benign hypoplasia.
sci-hub.se 参考文章(20)
Shangyuan Feng, Wenbo Wang, Isabella T. Tai, Guannan Chen, Rong Chen, Haishan Zeng, Label-free surface-enhanced Raman spectroscopy for detection of colorectal cancer and precursor lesions using blood plasma Biomedical Optics Express. ,vol. 6, pp. 3494- 3502 ,(2015) , 10.1364/BOE.6.003494
Pavel Matousek, Nicholas Stone, None, Development of deep subsurface Raman spectroscopy for medical diagnosis and disease monitoring Chemical Society Reviews. ,vol. 45, pp. 1794- 1802 ,(2016) , 10.1039/C5CS00466G
Alana L Mitchell, Ketan B Gajjar, Georgios Theophilou, Francis L Martin, Pierre L Martin‐Hirsch, None, Vibrational spectroscopy of biofluids for disease screening or diagnosis: translation from the laboratory to a clinical setting. Journal of Biophotonics. ,vol. 7, pp. 153- 165 ,(2014) , 10.1002/JBIO.201400018
Matthew J Baker, Júlio Trevisan, Paul Bassan, Rohit Bhargava, Holly J Butler, Konrad M Dorling, Peter R Fielden, Simon W Fogarty, Nigel J Fullwood, Kelly A Heys, Caryn Hughes, Peter Lasch, Pierre L Martin-Hirsch, Blessing Obinaju, Ganesh D Sockalingum, Josep Sulé-Suso, Rebecca J Strong, Michael J Walsh, Bayden R Wood, Peter Gardner, Francis L Martin, Using Fourier transform IR spectroscopy to analyze biological materials Nature Protocols. ,vol. 9, pp. 1771- 1791 ,(2014) , 10.1038/NPROT.2014.110
Changwon Lee, Randy P. Carney, Sidhartha Hazari, Zachary J. Smith, Alisha Knudson, Christopher S. Robertson, Kit S. Lam, Sebastian Wachsmann-Hogiu, 3D plasmonic nanobowl platform for the study of exosomes in solution. Nanoscale. ,vol. 7, pp. 9290- 9297 ,(2015) , 10.1039/C5NR01333J
José Luis González-Solís, Juan Carlos Martínez-Espinosa, Luis Adolfo Torres-González, Adriana Aguilar-Lemarroy, Luis Felipe Jave-Suárez, Pascual Palomares-Anda, Cervical cancer detection based on serum sample Raman spectroscopy. Lasers in Medical Science. ,vol. 29, pp. 979- 985 ,(2014) , 10.1007/S10103-013-1447-6
Greta Del Mistro, Silvia Cervo, Elena Mansutti, Riccardo Spizzo, Alfonso Colombatti, Pietro Belmonte, Renzo Zucconelli, Agostino Steffan, Valter Sergo, Alois Bonifacio, Surface-enhanced Raman spectroscopy of urine for prostate cancer detection: a preliminary study Analytical and Bioanalytical Chemistry. ,vol. 407, pp. 3271- 3275 ,(2015) , 10.1007/S00216-015-8610-9
David Perez-Guaita, Salvador Garrigues, Miguel de la, Guardia, Infrared-based quantification of clinical parameters Trends in Analytical Chemistry. ,vol. 62, pp. 93- 105 ,(2014) , 10.1016/J.TRAC.2014.06.012
Irène Tatischeff, Eric Larquet, Juan M. Falcón-Pérez, Pierre-Yves Turpin, Sergei G. Kruglik, Fast characterisation of cell-derived extracellular vesicles by nanoparticles tracking analysis, cryo-electron microscopy, and Raman tweezers microspectroscopy Journal of extracellular vesicles. ,vol. 1, pp. 19179- ,(2012) , 10.3402/JEV.V1I0.19179
Rebecca Siegel, Carol DeSantis, Katherine Virgo, Kevin Stein, Angela Mariotto, Tenbroeck Smith, Dexter Cooper, Ted Gansler, Catherine Lerro, Stacey Fedewa, Chunchieh Lin, Corinne Leach, Rachel Spillers Cannady, Hyunsoon Cho, Steve Scoppa, Mark Hachey, Rebecca Kirch, Ahmedin Jemal, Elizabeth Ward, Cancer treatment and survivorship statistics, 2012 CA: A Cancer Journal for Clinicians. ,vol. 62, pp. 220- 241 ,(2012) , 10.3322/CAAC.21149