The alteration of 5-HT2A and 5-HT2C receptors is involved in neuronal apoptosis of goldfish cerebellum following traumatic experience

摘要: Abstract 5-HT receptor changes remain controversial in posttraumatic stress disorder (PTSD) models. This study looks at the relationship between traumatic injuries and alterations 2A 2C receptors goldfish brain. The effect of treatment with doxepin fluoxetine, known to be selective serotonin reuptake inhibitor (SSRI) antidepressants, on expression fin ablation was also investigated. We demonstrated that induced anxiety-like behavioural significant up-regulation c-fos cerebellum. correlated well an increased cerebellum fish injury. An increase number apoptotic cells a higher caspase-8 protein level present brains compared control. Our findings suggest neuronal apoptosis occured as result may related levels beneficial clinical effects doxepin/fluoxetine are due down-regulation