A photoautotrophic platform for the sustainable production of valuable plant natural products from CO2

摘要: Many plant natural products have remarkable pharmacological activities. They are mainly produced directly by extraction from higher plants, which can hardly keep up with the surging global demand. Furthermore, over-felling of many medicinal plants has undesirable effects on ecological balance. In this study, we constructed a photoautotrophic platform unicellular cyanobacterium Synechococcus elongatus PCC7942 to convert greenhouse gas CO2 into an array valuable healthcare products, including resveratrol, naringenin, bisdemethoxycurcumin, p-coumaric acid, caffeic and ferulic acid. These six compounds be further branched other precious useful products. Various strategies introducing feedback-inhibition-resistant enzyme, creating functional fusion proteins, increasing malonyl-CoA supply been systematically investigated increase production. The highest titers these reached 4.1–128.2 mg L−1 system, highly comparable those obtained heterotrophic microorganisms using carbohydrates. Several advantages such as independence carbohydrate feedstocks, functionally assembling P450s, availability plentiful NADPH ATP support that photosynthetic is uniquely suited for producing This also provides green route direct conversion aromatic building blocks, promising alternative petrochemical-based production bulk compounds.