Structure-Activity Relationships at Dopaminergic Receptors

摘要: Publisher Summary This chapter discusses structure–activity relationships at dopaminergic receptors. Dopamine (DA) exerts a number of dose-dependent effects upon the mammalian cardiovascular system, including positive inotropic and chronotropic on heart, vasoconstriction, vasodilation. The first three these are because an action DA beta- or alpha-adrenergic However, involvement DA-specific receptors in vasodilatory effect has clearly been shown especially renal, coronary, cerebral arteries. Several experimental models for CNS receptor have introduced that allow much more severe analysis drug-DA interactions. from pharmacological point view. existence than one type may help explaining some discrepancies found receptor.