Canine distemper virus neutralization activity is low in human serum and it is sensitive to an amino acid substitution in the hemagglutinin protein.
作者： Eduard J. Sanders , Anatoli Kamali , Etienne Karita , Susan Allen , Pat Fast
DOI: 10.1016/J.VIROL.2015.03.035
关键词:
摘要: Serum was analyzed from 146 healthy adult volunteers in eastern Africa to evaluate measles virus (MV) and canine distemper (CDV) neutralizing antibody (nAb) prevalence potency. MV plaque reduction neutralization test (PRNT) results indicated that all sera were positive for nAbs. Furthermore, the 50% dose (ND50) majority of corresponded titers induced by vaccination. CDV nAbs low generally detected with high nAb titers. A mutant generated less sensitive human serum. The genome had 10 nucleotide substitutions, which coded single amino acid substitutions fusion (F) hemagglutinin (H) glycoproteins two large polymerase (L) protein. H substitution occurred a conserved region involved receptor interactions among morbilliviruses, implying this is target cross-reactive antibodies.
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