Cerebral Protein Turnover: Aspects and Problems

摘要: Our ideas and our knowledge about the mechanisms of cerebral protein synthesis degradation, metabolic rates these processes, factors which alter have undergone major changes in past few decades. Because complexity task, brain has not been examined this respect until comparatively recently. Due to technical difficulties, such as limited access labeled amino acids across blood-brain barrier, it was thought that turnover is very slow or absent nervous system, a unreasonable conclusion, considering lacks significant regenerative capacity site permanent information (memory). Now we know metabolism highly active involved many crucial functions neuropeptide formation enzyme activation. Both degradation undergo numerous development aging, they can be influenced by pathological environmental factors. It hoped further will open up variety therapeutic diagnostic possibilities. With PET may now possible study living human vivo, possibility only dreamed till