Changes in brain protein synthesis during the life span of male Fischer rats.

摘要: The cell-free protein synthetic activity of the postmitochondrial supernatant isolated from whole brain 6- to 32-month-old male Fischer F344 rats was compared. Protein synthesis decreased 56% 6 32 months age. decrease in not due an age-related increase RNase activity. Although monomeric ribosomes (ribosomes stripped mRNA) brains older were less active polyuridylic acid directed polyphenylalanine synthesis, fidelity translation by did with increasing