Biracial population study of mortality in mild cognitive impairment and Alzheimer disease.
作者： Robert S. Wilson , Neelum T. Aggarwal , Lisa L. Barnes , Julia L. Bienias , Carlos F. Mendes de Leon
DOI: 10.1001/ARCHNEUROL.2009.80
关键词:
摘要: Objective To assess mortality associated with mild cognitive impairment (MCI) and Alzheimer disease (AD) among older African Americans whites from an urban community. Design Longitudinal population-based observational study. Setting Four adjacent neighborhoods in Chicago, Illinois. Participants Persons deemed free of dementia a previous wave data collection (n = 1715) underwent detailed clinical evaluation: 802 had no (46.8%), 597 MCI (34.8%), 296 AD (17.3%), 20 other forms (1.2%). Main Outcome Measure All-cause mortality. Results During as many 10 years observation (mean [SD], 4.7 [3.0] years), 634 individuals died (37.0%). Compared people without impairment, risk death was increased by about 50% those (hazard ratio [95% confidence interval], 1.48 [1.22-1.80]) nearly 3-fold greater (2.84 [2.29-3.52]). These effects were seen did not differ race. Among participants MCI, more severe this effect vary A similar AD, but it slightly stronger for vs whites. In the groups, association survival perceptual speed than functions. Conclusion The presence severity are reduced Americans, these comparable to
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