摘要: Lipoproteins consist of lipids and apolipoproteins that have functional roles in lipid metabolism. It has been suggested oxidation lipoproteins by reactive oxygen species (ROS) may be involved the inception various diseases. In particular, relationship between low-density lipoprotein (LDL) atherosclerosis studied great detail. The main target molecules are polyunsaturated fatty acid residues apolipoproteins. Extensive investigations characterized oxidative modifications apolipoprotein B100 (apo B100) LDL. Furthermore, apo oxidized confirmed LDL atherosclerotic lesions using immunological techniques. this chapter, characteristics mechanisms ROS described from vitro vivo studies. Oxidative hydroperoxides, major products peroxidation at early stage, principally reported.
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sci-hub.se 参考文章(66)
Anitra C. Carr, Mark R. McCall, Balz Frei, Oxidation of LDL by Myeloperoxidase and Reactive Nitrogen Species Reaction Pathways and Antioxidant Protection Arteriosclerosis, Thrombosis, and Vascular Biology. ,vol. 20, pp. 1716- 1723 ,(2000) , 10.1161/01.ATV.20.7.1716
L J Hazell, J J M van den Berg, R Stocker, Oxidation of low-density lipoprotein by hypochlorite causes aggregation that is mediated by modification of lysine residues rather than lipid oxidation. Biochemical Journal. ,vol. 302, pp. 297- 304 ,(1994) , 10.1042/BJ3020297
Yoshichika Kawai, Hiroyuki Fujii, Miki Okada, Yoshikazu Tsuchie, Koji Uchida, Toshihiko Osawa, Formation of Nɛ-(succinyl)lysine in vivo: a novel marker for docosahexaenoic acid-derived protein modification Journal of Lipid Research. ,vol. 47, pp. 1386- 1398 ,(2006) , 10.1194/JLR.M600091-JLR200
Daniel Steinberg, The LDL modification hypothesis of atherogenesis: an update Journal of Lipid Research. ,vol. 50, ,(2009) , 10.1194/JLR.R800087-JLR200
Martin K. Jones, Jere P. Segrest, Nassrin Dashti, Hans De Loof, Structure of apolipoprotein B-100 in low density lipoproteins Journal of Lipid Research. ,vol. 42, pp. 1346- 1367 ,(2001) , 10.1016/S0022-2275(20)30267-4
Y Kato, Y Makino, T Osawa, Characterization of a specific polyclonal antibody against 13-hydroperoxyoctadecadienoic acid-modified protein: formation of lipid hydroperoxide-modified apoB-100 in oxidized LDL. Journal of Lipid Research. ,vol. 38, pp. 1334- 1346 ,(1997) , 10.1016/S0022-2275(20)37417-4
Chau Ly, Iron and atherosclerosis. Proceedings of the National Science Council, Republic of China. Part B, Life sciences. ,vol. 24, pp. 151- 155 ,(2000)
Rodney L. Levine, Nancy Wehr, Joy A. Williams, Earl R. Stadtman, Emily Shacter, Determination of Carbonyl Groups in Oxidized Proteins Methods of Molecular Biology. ,vol. 99, pp. 15- 24 ,(2000) , 10.1385/1-59259-054-3:15
H Itabe, T Imanaka, T Takano, J Kimura, E Takeshima, H Iwasaki, Y Yoshida, A monoclonal antibody against oxidized lipoprotein recognizes foam cells in atherosclerotic lesions. Complex formation of oxidized phosphatidylcholines and polypeptides. Journal of Biological Chemistry. ,vol. 269, pp. 15274- 15279 ,(1994) , 10.1016/S0021-9258(17)36602-4
FREDERICK T. HATCH, ROBERT S. LEES, Practical methods for plasma lipoprotein analysis. Advances in lipid research. ,vol. 6, pp. 1- 68 ,(1968) , 10.1016/B978-1-4831-9942-9.50008-5