Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics
作者： Simon Melov , Joanne Ravenscroft , Sarwatt Malik , Matt S Gill , David W Walker
DOI: 10.1126/SCIENCE.289.5484.1567
关键词:
摘要: We tested the theory that reactive oxygen species cause aging. augmented natural antioxidant systems of Caenorhabditis elegans with small synthetic superoxide dismutase/catalase mimetics. Treatment wild-type worms increased their mean life-span by a 44 percent, and treatment prematurely aging resulted in normalization (a 67 percent increase). It appears oxidative stress is major determinant it can be counteracted pharmacological intervention.
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