Facile synthesis, structural evaluation, antimicrobial activity and synergistic effects of novel imidazo[1,2- a ]pyridine based organoselenium compounds
作者： Sanjeev Kumar , Nidhi Sharma , Indresh K. Maurya , Aman K.K. Bhasin , Nishima Wangoo
DOI: 10.1016/J.EJMECH.2016.07.076
关键词:
摘要: A simple and efficient method has been described to synthesize the hitherto unknown imidazo[1,2-a]pyridine selenides (5a-l) by reaction of 2-chloroimidazo [1,2-a]pyridines with aryl/heteroaryl selenols, generated in situ reduction various diselenides hypophosphorous acid. The crystal structures 3-nitro-2-(phenylselanyl)-imidazo[1,2-a]pyridine (5a), 2-(mesitylselanyl)-3-nitro-imidazo[1,2-a]pyridine (5d) 3-nitro-2-(pyridin-2-ylselanyl)-imidazo[1,2-a]pyridine (5e) were confirmed X-ray crystallography DFT calculations performed determine structural parameters which correlated structures. synthesized compounds subjected antimicrobial evaluation it was found that 5a 5j active against gram negative bacterium Escherichia coli whereas compound 5e different fungal strains. Time kill assay understand microbial activity organoselenium toxicity these evaluated human cell lines. Synergistic effects tested existing antibiotic drugs exhibited combination efficiently enhanced activity.
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