Perturbation of mucosal-associated invariant T cells and iNKT cells in HIV infection.

摘要: Purpose of review To analyze the possible role that 'unconventional' T-cell populations mucosal-associated invariant T cell (MAIT) and iNKT cells play during HIV infection following antiretroviral therapy (ART) treatment. Recent findings A substantial body evidence now demonstrates both MAIT are depleted in blood infection. The depletion dysfunction only partially restored by suppressive ART, potentially contributing to HIV-related comorbidities. Summary deficiency subsets likely impact on immunity important coinfections including Mycobacterium tuberculosis. This underscores importance research restoring these unconventional Future studies this field should address challenge studying tissue-resident cells, particularly gut, better defining determinants MAIT/iNKT dysfunction. Such could have a significant improving immune function HIV-infected individuals.