Polymorphs with tyrosine kinase activity
作者： Matthew M. Zhao , Mark T. Bilodeau
DOI:
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摘要: The present invention relates to active polymorphs of 4-[2-(5-cyano-thiazol-2-ylamino)-pyridin-4-ylmethyl]-piperazine-1-carboxylic acid methylamide which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions contain these compounds, and methods using them treat kinase-dependent diseases conditions, such as angio-genesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, retinal ischemia, edema, inflammatory diseases, the like in mammals.
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