摘要: What is described a method of preventing or treating heterotopic ossification, vascular calcification, and pathologic mineralization, comprising administering an drug, wherein the drug antagonist Hedgehog (Hh) pathway. For example consists arsenic trioxide, sodium arsenite, phenylarsine, GANT-58, GANT-61, zerumbone vismodegib (GDC- 0449,Genentech), bevacizumab, gemcitabine, nab-paclitaxel, FOLFIR, FOLFOX, RO4929097, cixutumumab, cisplatin, etoposide, LDAC, decitabine, daunorubicin, cytarabin, rosiglitazone, goserelin, leuprolide, capecitabine, fluorouracil, leucovorin, oxaliplatin, irinotecan, diclofenac, BMS-833923 (XL139), IPI-926- Infinity Pharmaceuticals, Inc., LDE225, LEQ506-Novartis TAK-441 Millennium PF-04449913-Pfizer, alone in combination therapy. The targets pluripotent mesenchymal cells, inhibits expression gene encoding Hh pathway component, for by decreasing levels mRNA encoded Ptch1, Gli1 HIP.
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