The life of regulatory T cells
作者： Iris K. Gratz , Michael D. Rosenblum , Abul K. Abbas
DOI: 10.1111/NYAS.12011
关键词:
摘要: Foxp3(+) regulatory T (Treg ) cells are essential for maintaining self-tolerance and preventing autoimmune reactions. Treg arise as a consequence of self-antigen recognition during the maturation in thymus, also following periphery. Both thymic peripherally generated respond to antigen by expanding number, increasing their suppressive activity, accumulating tissue where is located. A fraction these activated "effector" survive even absence expression continue control inflammatory reaction tissues, thus functioning population "memory" cells. Antigen exposure presence IL-2 key determinants generation memory These results provide foundation studying role controlling treating disorders testing hypothesis that defects maintenance underlie chronic, relapsing diseases.
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