作者: Leigh M. Henderson , Günter Speit
DOI: 10.1016/J.MRREV.2004.12.001
关键词:
摘要: Styrene (CAS No. 100-42-5) is an important industrial chemical for which positive results have been reported in vitro and vivo genotoxicity assays. Styrene-exposed workers studied extensively over two decades the induction of various types genotoxic effects. The outcomes these studies conflicting, where responses reported, it has proved difficult to demonstrate clear relationships between levels damage exposure levels. In this review, we assessed addressing mutagenicity (chromosome aberrations, micronuclei gene mutations) other endpoints (sister chromatid exchanges, DNA breaks adducts) using criteria derived from IPCS guidelines conduct human biomonitoring studies. Based on re-evaluated outcomes, data are not convincing that styrene induces mutations. evidence clastogenicity occupationally exposed less clear, with a predominant lack different studies, but conflicting chromosome aberration numerous sister exchanges do provide response, despite being induced animals at high concentrations. However, there both adducts single strand workers. These considered indicative target cells interaction cellular necessarily result heritable changes. There metabolism humans affected by genetic polymorphisms metabolizing genes affect outcome styrene. Therefore, addressed potential factor were considered. To date, no consistent humans, further work warranted larger samples. analyses individual together consideration dose-response common profile detectable mutagenic damage. metabolites demonstrated formation breaks.