Review of the genotoxicity of styrene in humans.

作者: Leigh M. Henderson , Günter Speit

DOI: 10.1016/J.MRREV.2004.12.001

关键词:

摘要: Styrene (CAS No. 100-42-5) is an important industrial chemical for which positive results have been reported in vitro and vivo genotoxicity assays. Styrene-exposed workers studied extensively over two decades the induction of various types genotoxic effects. The outcomes these studies conflicting, where responses reported, it has proved difficult to demonstrate clear relationships between levels damage exposure levels. In this review, we assessed addressing mutagenicity (chromosome aberrations, micronuclei gene mutations) other endpoints (sister chromatid exchanges, DNA breaks adducts) using criteria derived from IPCS guidelines conduct human biomonitoring studies. Based on re-evaluated outcomes, data are not convincing that styrene induces mutations. evidence clastogenicity occupationally exposed less clear, with a predominant lack different studies, but conflicting chromosome aberration numerous sister exchanges do provide response, despite being induced animals at high concentrations. However, there both adducts single strand workers. These considered indicative target cells interaction cellular necessarily result heritable changes. There metabolism humans affected by genetic polymorphisms metabolizing genes affect outcome styrene. Therefore, addressed potential factor were considered. To date, no consistent humans, further work warranted larger samples. analyses individual together consideration dose-response common profile detectable mutagenic damage. metabolites demonstrated formation breaks.

参考文章(92)
Järventaus H, Kubiak R, Pekari K, Pfäffli P, Nylander L, Sorsa M, Anttila A, Norppa H, Vainio H, Styrene revisited--exposure assessment and risk estimation in reinforced plastics industry. Progress in Clinical and Biological Research. ,vol. 372, pp. 187- ,(1991)
W.M. Paradisin, S.M. Rappaport, E. Symanski, J.W. Yager, Sister chromatid exchanges induced in peripheral lymphocytes of workers exposed to low concentrations of styrene. Progress in Clinical and Biological Research. pp. 347- 356 ,(1990)
Samuel A. Latt, Rhona R. Schreck, Kenneth S. Loveday, Charlotte P. Dougherty, Charles F. Shuler, Sister Chromatid Exchanges Advances in human genetics. ,vol. 10, pp. 267- 331 ,(1980) , 10.1007/978-1-4615-8288-5_4
A. Forni, E. Goggi, E. Ortisi, R. Cecchetti, G. Cortona, G. Sesana, L. Alessio, Cytogenetic Findings in Styrene Workers in Relation to Exposure Springer, Berlin, Heidelberg. pp. 159- 162 ,(1988) , 10.1007/978-3-642-73766-4_34
Wolfgang Hadnagy, Norbert H. Seemayer, Environmental Hygiene II ,(1990)
R.J. Albertini, M.L. Mendelsohn, Mutation and the environment-Part B New York, NY (USA); John Wiley and Sons Inc.. ,(1990)
Pavel Vodička, Tatiana Tvrdik, Siv Osterman-Golkar, Ludmila Vodičková, Kateřina Peterková, Pavel Souček, Jana Šarmanová, Peter B Farmer, Fredrik Granath, Bo Lambert, Kari Hemminki, An evaluation of styrene genotoxicity using several biomarkers in a 3-year follow-up study of hand-lamination workers. Mutation Research-genetic Toxicology and Environmental Mutagenesis. ,vol. 445, pp. 205- 224 ,(1999) , 10.1016/S1383-5718(99)00127-8
Alessio Naccarati, Alessia Zanello, Stefano Landi, Roberta Consigli, Lucia Migliore, Sperm-FISH analysis and human monitoring: a study on workers occupationally exposed to styrene. Mutation Research-genetic Toxicology and Environmental Mutagenesis. ,vol. 537, pp. 131- 140 ,(2003) , 10.1016/S1383-5718(03)00081-0
Pavel Soucek, Ludmila Vodicková, Pavel Hlavác, Miroslava Kuricová, Radka Necasová, Kari Hemminki, Pavel Vodicka, Rudolf Stetina, Mikko Koskinen, New aspects in the biomonitoring of occupational exposure to styrene. International Archives of Occupational and Environmental Health. ,vol. 75, pp. 75- 85 ,(2002) , 10.1007/S00420-002-0357-X