Genotoxicity and metabolism of chromium compounds

摘要: This article reviews studies and new experimental data concerning the genotoxicity of chromium compounds different oxidation state in a variety short‐term test systems, as well their metabolic fate. The chemical or biochemical reduction Cr(VI) has been investigated several body fluids cell preparations tissues from various animal species, including humans. variability factors involved underlying mechanisms have explored. selective sites organism may be consistent with its lack carcinogenicity by oral route at distance administration sites. Also lung, is likely to limited defense lower respiratory tract, such those provided epithelial‐lining fluid alveolar macrophages.