Regulation of the α-secretase ADAM10 at transcriptional, translational and post-translational levels.

摘要: A tremendous gain of interest in the biology ADAM10 emerged during past 15 years when it has first been shown that this protease was able to target α-site β-amyloid precursor protein (βAPP) and later confirmed as main physiological α-secretase activity. However, beside its well-established implication so-called non-amyloidogenic processing βAPP probable protective role against Alzheimer's disease (AD), metalloprotease also cleaves many other substrates, thereby being implicated various well pathological processes such cancer inflammation. Thus, view possible effective therapeutic interventions, a full comprehension how is up down regulated required. This review discusses our current knowledge concerning enzyme AD more recently established roles brain disorders provides detailed up-date on transcriptional, translational post-translational modulations.