Enzyme/pH dual-responsive polymer prodrug nanoparticles based on 10-hydroxycamptothecin-carboxymethylchitosan for enhanced drug stability and anticancer efficacy
作者： Xi Pan , Jingru Chen , Mengdan Yang , Jie Wu , Guanghua He
DOI: 10.1016/J.EURPOLYMJ.2019.04.050
关键词:
摘要: … papain is relatively easy to obtain, so Cathepsin B was replaced with Papain for in vitro drug release … In order to investigate the effect of enzyme on the drug release at pH 7.4, papain …
sci-hub.se 参考文章(40)
Anna Shenderova, Thomas G. Burke, Steven P. Schwendeman, Stabilization of 10-hydroxycamptothecin in poly(lactide-co-glycolide) microsphere delivery vehicles. Pharmaceutical Research. ,vol. 14, pp. 1406- 1414 ,(1997) , 10.1023/A:1012172722246
Andrew Cstorer, Robert Ménard, Catalytic mechanism in papain family of cysteine peptidases. Methods in Enzymology. ,vol. 244, pp. 486- 500 ,(1994) , 10.1016/0076-6879(94)44035-2
Zhuxian Zhou, William J. Murdoch, Youqing Shen, A linear polyethylenimine (LPEI) drug conjugate with reversible charge to overcome multidrug resistance in cancer cells Polymer. ,vol. 76, pp. 150- 158 ,(2015) , 10.1016/J.POLYMER.2015.08.061
J.R. Kimmel, Emil L. Smith, Crystalline papain. I. Preparation, specificity, and activation. Journal of Biological Chemistry. ,vol. 207, pp. 515- 531 ,(1954) , 10.1016/S0021-9258(18)65669-8
L YANG, F CUI, D CUN, A TAO, K SHI, W LIN, Preparation, characterization and biodistribution of the lactone form of 10-hydroxycamptothecin (HCPT)-loaded bovine serum albumin (BSA) nanoparticles International Journal of Pharmaceutics. ,vol. 340, pp. 163- 172 ,(2007) , 10.1016/J.IJPHARM.2007.03.028
YAN-JUN ZHONG, LI-HUA SHAO, YAN LI, Cathepsin B-cleavable doxorubicin prodrugs for targeted cancer therapy (Review) International Journal of Oncology. ,vol. 42, pp. 373- 383 ,(2013) , 10.3892/IJO.2012.1754
Y. Tanaka, R. Tanaka, T. Kawabata, Y. Noguchi, M. Himeno, Lysosomal cysteine protease, cathepsin B, is targeted to lysosomes by the mannose 6-phosphate-independent pathway in rat hepatocytes: site-specific phosphorylation in oligosaccharides of the proregion. Journal of Biochemistry. ,vol. 128, pp. 39- 48 ,(2000) , 10.1093/OXFORDJOURNALS.JBCHEM.A022728
F Bengsch, A Buck, S C Günther, J R Seiz, M Tacke, D Pfeifer, D von Elverfeldt, L Sevenich, L E Hillebrand, U Kern, M Sameni, C Peters, B F Sloane, T Reinheckel, Cell type-dependent pathogenic functions of overexpressed human cathepsin B in murine breast cancer progression Oncogene. ,vol. 33, pp. 4474- 4484 ,(2014) , 10.1038/ONC.2013.395
Nirmalkumar Vijayalakshmi, Abhijit Ray, Alexander Malugin, Hamidreza Ghandehari, Carboxyl-terminated PAMAM-SN38 conjugates: synthesis, characterization, and in vitro evaluation. Bioconjugate Chemistry. ,vol. 21, pp. 1804- 1810 ,(2010) , 10.1021/BC100094Z
Lu Guangyuan, Sheng Baiyang, Wang Gan, Wei Yujun, Gong Yandao, Zhang Xiufang, Zhang Lihai, Controlling the degradation of covalently cross-linked carboxymethyl chitosan utilizing bimodal molecular weight distribution. Journal of Biomaterials Applications. ,vol. 23, pp. 435- 451 ,(2009) , 10.1177/0885328208091661