Regulation of the β2-adrenergic receptor and its mRNA in the rat ventral prostate by testosterone
作者： Sheila Collins , Valerie E. Quarmby , Frank S. French , Robert J. Lefkowitz , Marc G. Caron
DOI: 10.1016/0014-5793(88)81378-4
关键词:
摘要: Abstract To investigate the regulation of β 2 AR expression in rat ventral prostate effects castration and testosterone replacement on were studied by ligand binding Northern blot analysis. Orchidectomy depressed number 50% within 4 days administration to 4-day castrates produced a rapid complete recovery 24 h. In contrast receptor number, mRNA levels did not change relative total RNA following castration. However, during period rose transiently, reaching maximum (3.5-fold) between 8 12 h, this increase preceded membrane. Regulation gene is thus complex probably involves both transcriptional post-transcriptional components.
core.ac.uk
elsevier.com
sci-hub.se 参考文章(26)
B K Kobilka, T Frielle, H G Dohlman, M A Bolanowski, R A Dixon, P Keller, M G Caron, R J Lefkowitz, Delineation of the intronless nature of the genes for the human and hamster beta 2-adrenergic receptor and their putative promoter regions. Journal of Biological Chemistry. ,vol. 262, pp. 7321- 7327 ,(1987) , 10.1016/S0021-9258(18)48239-7
T Noguchi, M Diesterhaft, D Granner, Evidence for a dual effect of dibutyryl cyclic AMP on the synthesis of tyrosine aminotransferase in rat liver. Journal of Biological Chemistry. ,vol. 257, pp. 2386- 2390 ,(1982) , 10.1016/S0021-9258(18)34934-2
P A Insel, L C Mahan, Expression of beta-adrenergic receptors in synchronous and asynchronous S49 lymphoma cells. I. Receptor metabolism after irreversible blockade of receptors and in cells traversing the cell division cycle. Molecular Pharmacology. ,vol. 29, pp. 7- 15 ,(1986)
J E Kalinyak, A J Perlman, Tissue-specific regulation of angiotensinogen mRNA accumulation by dexamethasone. Journal of Biological Chemistry. ,vol. 262, pp. 460- 464 ,(1987) , 10.1016/S0021-9258(19)75949-3
Hiroshi Kouyama, Masanao Hirai, Mikio Asakura, Sumio Shima, Yoshiko Kawashima, Effects of androgens on isoproterenol-sensitive adenylate cyclase system of the rat prostate. Molecular Pharmacology. ,vol. 18, pp. 45- 48 ,(1980)
Don W. Cleveland, Margaret A. Lopata, Raymond J. MacDonald, Nicholas J. Cowan, William J. Rutter, Marc W. Kirschner, Number and evolutionary conservation of α- and β-tubulin and cytoplasmic β- and γ-actin genes using specific cloned cDNA probes Cell. ,vol. 20, pp. 95- 105 ,(1980) , 10.1016/0092-8674(80)90238-X
S. Hashimoto, W. Schmid, G. Schutz, Transcriptional activation of the rat liver tyrosine aminotransferase gene by cAMP Proceedings of the National Academy of Sciences of the United States of America. ,vol. 81, pp. 6637- 6641 ,(1984) , 10.1073/PNAS.81.21.6637
T. Frielle, S. Collins, K. W. Daniel, M. G. Caron, R. J. Lefkowitz, B. K. Kobilka, Cloning of the cDNA for the human beta 1-adrenergic receptor. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 84, pp. 7920- 7924 ,(1987) , 10.1073/PNAS.84.22.7920
B. Kobilka, H Matsui, T. Kobilka, T. Yang-Feng, U Francke, M. Caron, R. Lefkowitz, J. Regan, Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor Science. ,vol. 238, pp. 650- 656 ,(1987) , 10.1126/SCIENCE.2823383
Nobuyuki Itoh, Hiroshi Okamoto, Translational control of proinsulin synthesis by glucose Nature. ,vol. 283, pp. 100- 102 ,(1980) , 10.1038/283100A0