Gene expression after vaccination of mice with formulations of diphtheria toxoid or tetanus toxoid and different adjuvants: identification of shared and vaccine-specific genes in spleen lymphocytes.

作者: Karin Regnström , Eva Ragnarsson , Per Artursson

DOI: 10.1016/S0264-410X(03)00103-8

关键词:

摘要: We immunized mice with four different combinations of diphtheria toxoid or tetanus aluminum phosphate Freund's adjuvant and studied the resulting gene expression profiles in spleen lymphocytes. Genes, which are unique for each combination shared several combinations, were found activated, functions immune response but also other cellular processes like apoptosis signal transduction. Using bioinformatic tools we show, that some genes may serve as indicators adverse reactions, while be new markers. The results suggest participates formation an immunological memory.

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