The Neuropharmacology of Ethanol Self-Administration

摘要: The abuse liability of ethanol is thought to derive primarily from its anxiolytic and euphoric effects. Together, these properties are believed underlie the acute reinforcing actions that, in turn, sustain continued thereby ultimately may lead development dependence. An increasing body evidence suggests that rewarding intoxicating effects mediated by on one or more specific neurotransmitter systems brain (Faber Klee, 1977; Kulonen, 1983; Liljequist Engel, 1979; Myers, 1978b; Tabakoff, 1977). However, although there tentative linking certain transmitters—notably catecholamines, opioids, gamma-amino butyric acid serotonin—or their receptors aspects ethanol, no exclusive role for any transmitter reward dependence has yet been established.