作者: David R. Brown , Stephen G. Holtzman
DOI: 10.1016/0091-3057(79)90043-1
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摘要: Abstract Naloxone, an opiate antagonist, was administered to male and female rats mice after periods of food or water deprivation ranging from 12 48 hr. Naloxone (0.01–10 mg/kg) reduced postdeprivational intake in most groups a dose-related manner. suppression consumption appeared be independent sexual differences rats, phase the diurnal cycle, length interval both mice. Postdeprivational also by naloxone dose-dependent fashion. This effect less pronounced than actions observed with intake, tended diminish lengthening periods. In general, sensitive intake. appears markedly reduce appetitive behavior, particularly following The fact that low doses can elicit these effects suggests drug is acting at specific tissue sites, possibly endorphin receptors.