Suppression of deprivation-induced food and water intake in rats and mice by naloxone.

作者: David R. Brown , Stephen G. Holtzman

DOI: 10.1016/0091-3057(79)90043-1

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摘要: Abstract Naloxone, an opiate antagonist, was administered to male and female rats mice after periods of food or water deprivation ranging from 12 48 hr. Naloxone (0.01–10 mg/kg) reduced postdeprivational intake in most groups a dose-related manner. suppression consumption appeared be independent sexual differences rats, phase the diurnal cycle, length interval both mice. Postdeprivational also by naloxone dose-dependent fashion. This effect less pronounced than actions observed with intake, tended diminish lengthening periods. In general, sensitive intake. appears markedly reduce appetitive behavior, particularly following The fact that low doses can elicit these effects suggests drug is acting at specific tissue sites, possibly endorphin receptors.

参考文章(38)
M TERHAAR, Circadian and estrual rhythms in food intake in the rat Hormones and Behavior. ,vol. 3, pp. 213- 219 ,(1972) , 10.1016/0018-506X(72)90034-7
R.P. Maickel, Monique C. Braude, J.E. Zabik, The effects of various narcotic agonists and antagonists on deprivation-induced fluid consumption Neuropharmacology. ,vol. 16, pp. 863- 866 ,(1977) , 10.1016/0028-3908(77)90149-6
T BURKS, N DAFNY, Naloxone and morphine effects on sensory evoked responses Neuropharmacology. ,vol. 16, pp. 681- 686 ,(1977) , 10.1016/0028-3908(77)90120-4
L. P. Morin, Alison S. Fleming, Variation of food intake and body weight with estrous cycle, ovariectomy, and estradiol benzoate treatment in hamsters (Mesocricetus auratus). Journal of Comparative and Physiological Psychology. ,vol. 92, pp. 1- 6 ,(1978) , 10.1037/H0077435
KEITH OATLEY, Dissociation of the circadian drinking pattern from eating. Nature. ,vol. 229, pp. 494- 496 ,(1971) , 10.1038/229494A0
G.C. Davis, M.S. Buchsbaum, W.E. Bunney, Naloxone decreases diurnal variation in pain sensitivity and somatosensory evoked potentials. Life Sciences. ,vol. 23, pp. 1449- 1459 ,(1978) , 10.1016/0024-3205(78)90126-1
Harbans Lal, Steven Miksic, Nelson Smith, Naloxone antagonism of conditioned hyperthermia: an evidence for release of endogenous opioid. Life Sciences. ,vol. 18, pp. 971- 975 ,(1976) , 10.1016/0024-3205(76)90417-3