Evaluating the interaction of a tracheobronchial stent in an ovine in-vivo model.

摘要: Tracheobronchial stents are used to restore patency stenosed airways. However, these devices associated with many complications such as stent migration, granulation tissue formation, mucous plugging and strut fracture. Of these, formation is the complication that most frequently requires costly secondary interventions. In this study a biomechanical lung modelling framework recently developed by authors capture in-vivo stress state under physiological loading employed in conjunction ovine pre-clinical stenting results device experimental data evaluate effect of interaction on formation. Stenting simulated using validated model prototype covered laser-cut tracheobronchial semi-specific model, performed. Two computational methods then predict possible formation: standard method which utilises increase maximum principal change, newly proposed compares change contact pressure over respiratory cycle. These predictions compared observations after 6-week implantation period. Experimental showed signs both proximally distally, greater proximal reaction. The failed show correlation results. an apparent suggest new could be tool improve future designs.