Clustered Nanocarriers: The Effect of Size on the Clustering of CCMV Virus‐Like Particles With Soft Macromolecules

摘要: Virus-like particles (VLP) could enable a wide variety of biomedical applications in therapy, drug delivery, and imaging. They are biocompatible can be self-assembled into larger structured materials for additional functionality potentially better biodistribution, which is still challenging aspect. Here we investigate the role VLPs size resulting Caspar Klug symmetry forming clusters out these building blocks, showing that onset point clustering determined by steric considerations binding site agent. The independent cargo data suggests rotational T = 3 capsid allows hexagonal close packed structures, whereas T = 1 lacks six-fold twofold axis does not show such organization.