Comprehensive Proteomic Analysis Reveals Intermediate Stage of Non-Lesional Psoriatic Skin and Points out the Importance of Proteins Outside this Trend.

摘要: To better understand the pathomechanism of psoriasis, a comparative proteomic analysis was performed with non-lesional and lesional skin from psoriasis patients healthy individuals. Strikingly, 79.9% proteins that were differentially expressed in exhibited expression levels within twofold observed skin, suggesting represents an intermediate stage. Proteins outside this trend categorized into three groups: I. exhibiting similar to which might be predisposing factors (i.e., CSE1L, GART, MYO18A UGDH); II. but not characteristic alteration CHCHD6, CHMP5, FLOT2, ITGA7, LEMD2, NOP56, PLVAP RRAS); III. contrasting differential compared contribute maintaining state ITGA8, PLVAP, PSAPL1, SMARCA5 XP32). Finally, lesions may indicate increased sensitivity stimuli, peripheral nervous system alterations, furthermore MYBBP1A PRKDC identified as potential regulators key pathomechanisms, including stress immune response, proliferation differentiation.