TRAIL-R2 is not correlated with p53 status and is rarely mutated in non-small cell lung cancer

摘要: Background: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptors play an important role in regulating apoptosis. Recently, it was shown that the expression of TRAIL-R2, also known as KILLER, Trick or DR5, can be induced by either DNA damage overexpression a wild-type p53 transgene, suggesting for death-signaling pathway. Furthermore, mutations death domain TRAIL-R2 were reported 10.6% non-small cell lung cancer (NSCLC) patients Korean population, tumorigenesis. Materials and methods: To determine association between mutation status cancers, we compared two events 20 small-cell (SCLC) lines, NSCLC 30 primary tumors. We sequenced total 100 NSCLC. Results: Lack found eight (40%) SCLC lines eleven (55%) lines. Interestingly, NSCLC, overexpressed seven (23%) tumors tested, all expressed No tumors, Further analysis failed to identify any Conclusions: Our data indicate profile is significantly different independent from minimal NSCLCs white Americans.