Bone marrow necrosis

摘要: Abstract The clinical findings of bone marrow necrosis in 13 patients undergoing examination to investigate a peripheral blood cytopenia or leukoerythroblastic smear were reviewed and compared those the literature. Excluding sickle cell disease, all cases diagnosed during life associated with neoplastic process involving marrow. A myeloproliferative disorder was found five patients, metastatic carcinoma lymphoma two both one patient. Marrow involve at multiple sites piecemeal fashion areas necrotic structurally intact adjacent each other. Severe pain without roentgenographic abnormality major symptom 85 per cent patients. fat emboli, hypercalcemia cytopenias identified as direct complications necrosis. prognosis secondary disease be extremely poor median survival less than month. However, patient responded antineoplastic chemotherapy showed healing