Obesity and Cancer Metabolism: A Perspective on Interacting Tumor–Intrinsic and Extrinsic Factors
作者： Steven S. Doerstling , Ciara H. O’Flanagan , Stephen D. Hursting
关键词:
摘要: Obesity is associated with increased risk and poor prognosis of many types cancers. Several obesity-related host factors involved in systemic metabolism can influence tumor initiation, progression, and/or response to therapy, these have been implicated as key contributors the complex effects obesity on cancer incidence outcomes. Such include metabolic regulators including insulin, insulin-like growth factor 1, adipokines, inflammation-related molecules, steroid hormones, well cellular structural components microenvironment, particularly adipose tissue. These secreted are extrinsic to, interact with, intrinsic characteristics cells their spread. This review will focus interplay cell-intrinsic context energy balance, objective identifying new intervention targets for preventing obesity-associated cancer.
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