Interpreting the association between cannabis use and increased risk for schizophrenia.

摘要: Recent longitudinal studies from Sweden, the Netherlands, New Zealand, and Israel report that cannabis use during childhood adolescence doubles risk of later appearance psychosis or schizophrenia, These data have been interpreted as indicating has a causal effect along pathway to psychosis. In this paper, we will offer an alternative explanation these data. investigations patients with schizophrenia found increased density cannabinoid receptors in dorsolateral prefrontal cortex anterior cingulate cortex. Others reported higher levels endogenous cannabinoids blood cerebrospinal fluid patients; findings were independent possible use. Several genetic association between genes encoding receptor schizophrenia. Thus, might be pathology system is associated both rates for without being factor