Preparation of chiral amides and amines

摘要: This invention provides a convenient method for converting oximes into enamides. The process does not require the use of metallic reagents. Accordingly, it produces desired compounds without concomitant production large volume waste. enamides are useful precursors to amides and amines. convert prochiral enamide corresponding chiral amide. In an exemplary process, amino center is introduced during hydrogenation through catalyst. selected embodiments, methods preparing amines that include 1,2,3,4-tetrahydro-N-alkyl-1-naphthalenamine or 1,2,3,4-tetrahydro-1-naphthalenamine substructure.