Long-Term Renal Function in Patients with Irradiated Bilateral Wilms Tumor

摘要: The treatment of bilateral Wilms tumor (BWT) involves a multidisciplinary approach including surgery, chemotherapy, and radiation therapy. long-term renal function in patients receiving all three modalities has not been evaluated. Long-term was evaluated 81 children with synchronous BWT who received therapy as part their treatment. Renal assessed by measuring blood urea nitrogen (BUN) serum creatinine (Cr). normal range for the BUN defined 10-24 mg/dl, Cr considered at levels 50 mg/dl and/or >2.5 mg/ dl. were measured prior to following intervals: 6 months after treatment, I year 2 years last follow-up. Any elevation during posttreatment follow-up period abnormal. A total 28 (34.6%) had elevated levels, 18 moderate 10 marked insufficiency. No dose-response relationship established when comparing doses those values values. complication rate moderate, other factors extent nature recurrent must also be taken into account. elevations present several could attributed recurrence one case gentamicin toxicity. management should consider these risks, attempts preserve parenchyma are warranted.