A progressive glomerulosclerosis occurring in partial five-sixths nephrectomized rats.

摘要: A chronic renal disease was induced by 5/6 nephrectomy in young adult Wistar albino male rats. Groups of 3 rats were killed at varying time intervals from 10 to 50 weeks after nephrectomy, and the glomerular structure studied light electron microscopy. By microscopy, increase size hypertrophy visceral epithelial cells evident as early tenth week. Significant degree hyalinization started on 25th week gradually became more extensive involvement towards 50th miscroscopy, hypertrophied epithelia showed many osmiophilic bodies vacuoles their cytoplasm fusion foot processes. Beginning 30th week, mesangial matrix quite evident, endothelial disappeared areas where prominent. The increased encroached occluded capillary lumina Bowman's space, leading a formation obsolescent glomeruli. Whether or not these changes are due hyperfiltration which has been known occur remains be elucidated.