The effect of Diabetes on outcomes of Patients with advanced heart failure in the BEST trial

摘要: Objectives This was a retrospective analysis to determine the effect of diabetes on outcome in patients with advanced heart failure (HF), and beta-blockade HF without mellitus. Background In chronic impact clinical outcomes therapeutic response prevalent comorbid condition mellitus has not been extensively investigated. Methods We assessed prognosis effectiveness beta-blocker therapy bucindolol enrolled Beta-Blocker Evaluation Survival Trial (BEST). conducted examine diabetes, mortality progression or myocardial infarction (MI). The database 2,708 (36% 64% diabetes) who were randomized placebo BEST followed for mortality, hospitalization, MI an average two years. Results Patients had more severe coronary risk factors than diabetes. Diabetes independently associated increased ischemic cardiomyopathy (adjusted hazard ratio 1.33, 95% confidence interval 1.12 1.58, p = 0.001), but those nonischemic etiology 0.98, 0.74 1.30, 0.89). Compared diabetic at least as effective reducing death hospitalizations, total MI. Ventricular function physiologic responses similar diabetes. Conclusions worsens HF, this worsening appears be limited cardiomyopathy. is major end points