Graft-versus-myeloma effect: proof of principle

摘要: The presence of a graft-versus-tumor effect has been well established in leukemia but not multiple myeloma. A 40-year-old patient with myeloma refractory to standard chemotherapy and autologous transplantation received matched unrelated T-cell-depleted transplant after conditioning fractionated total-body irradiation, thiotepa, cyclophosphamide. This procedure resulted transient incomplete response evidence rapidly progressive disease within 2.5 months posttransplantation. then small number donor peripheral blood (PB) mononuclear cells (CD3 1.2 x 10(6)/kg) without any further cytotoxic therapy. complete remission was attained, lasting now for more than 14 months. associated severe acute subsequently limited chronic graft- versus-host (GVHD). report provides the first direct graft-versus-myeloma allogenic transplantation.