Direct silanization of zirconia for increased biointegration.

摘要: Abstract High-performance bioinert ceramics such as zirconia have been used for biomedical devices since the early seventies. In order to promote osseointegration, historical solution has increase specific surface of implant through roughness. Nevertheless these treatments on may create defects at surface, exposing material higher chances failure. zirconia, also affect stability surface. More recently, interest improving osseointegration implants moved research focus towards actual chemistry Inspired by this, we adapted current knowledge and techniques silica functionalization applied it successfully introduce 3-aminopropyldimethylethoxy silane (APDMES) directly (3Y-TZP). We plasma oxygen clean hydroxylation density. The samples were extensively characterized means X-ray photoelectron spectroscopy (XPS) contact angle, mechanically tested its cytotoxicity was evaluated cell adhesion proliferation tests. Additionally, aging studied discard negative effects treatment tetragonal phase. No adverse effect found mechanical response treated samples. addition, plasma-treated exhibited an unexpectedly resistance aging. Finally, density 35% lower than one reported in literature silica. However cells displayed a qualitatively spreading opposition rounder appearance untreated zirconia. These results lay foundations next generation with biologically friendlier surfaces. Statement Significance use zirconia-based is broad well accepted, especially dental implants. However, they do not bond naturally bone, therefore ensure fixation surgeons typically rely roughness different scales, or cements. Alternatively this work present new perspective modification enhance interaction between biological environment, without downsides This proposed which allowed direct silanization attachment. open possibility ceramic more advanced tailored surfaces increased osseointegration.