Misdirection and guidance of regenerating axons after experimental nerve injury and repair.

摘要: Misdirection of regenerating axons is one the factors that can explain limited results often found after nerve injury and repair. In repair mixed nerves innervating different distal targets (skin muscle), misdirection may, for example, lead to motor projecting toward skin, vice versa-that is, sensory muscle. targets, may result in reinnervation wrong target muscle, which might function antagonistically. repair, give an increased perceptual territory. After median this a dysfunctional hand. Different be involved axons, there various mechanisms later correct misdirection. review authors discuss these act along pathway axon. The recently developed evaluation methods used investigate accuracy regeneration (including use transgenic fluorescent mice, retrograde tracing techniques, motion analysis). addition, new strategies improve vivo guidance physical with multichannel tubes biological accomplished using gene therapy).