Morphological Proof of nerve regeneration after long-term defects of rat sciatic nerves

摘要: Unsatisfactory efficacy of clinical cure for long-term delayed injuries and other disadvantages such as the low regeneration rate speed axotomized neurons questionable reinnervation ability atrophic target organ lead to inaction injuries. Here we attempted use autologous nerve bridge a 10-mm defect in SD rats based on some previous positive messages basic research. In this study, experimental groups, rat sciatic had been transected leaving defect, which was maintained 3 or 6 months before implantation with graft. The non-grafted animals served negative control. Measuring electrophysiological histological techniques, find: (1) A number survived sustained certain degree axonal regenerative capacity; (2) few denervated Schwann cells retained their provide trophic support myelinate axons at least months; (3) chronically muscle can partially be reinnervated by regenerated axons. But quantity quality fibers were all poor. Thus these observations new morphological proof after defects further studies will needed increase survival chronic neurons, enhance provided distal stumps protect muscle.