Novartis Malaria Initiative: best practice example of pharmaceutical industry's engagement in the fight against malaria.
作者： Gilbert Lefèvre , Anne Claire Marrast , Heiner Grueninger
DOI: 10.1111/J.1749-6632.2011.05973.X
关键词:
摘要: Despite considerable advances in the treatment and prevention of malaria, Plasmodium falciparum is still a threat to millions people across world, particularly sub-Saharan Africa, with infants young children bearing greatest burden terms morbidity mortality. Since 1999, artemisinin-based combination therapy artemether-lumefantrine (AL; Coartem) has been made available. A wealth evidence supports consistently high efficacy AL, favorable safety tolerability profile demonstrated. The child-friendly dispersible formulation AL proven be as effective well tolerated standard tablets, will encourage ease administration improved adherence drug regimen. This article reviews significant impact by on progress malaria control describes way forward for Novartis Malaria Initiative leading fight against malaria.
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harvard.edu参考文章(66)
Te-Yu Hung, Timothy M. E. Davis, Kenneth F. Ilett, Harin Karunajeewa, Sean Hewitt, Mey Bouth Denis, Chiv Lim, Doung Socheat, Population pharmacokinetics of piperaquine in adults and children with uncomplicated falciparum or vivax malaria British Journal of Clinical Pharmacology. ,vol. 57, pp. 253- 262 ,(2003) , 10.1046/J.1365-2125.2003.02004.X
Christopher J.M. Whitty, Sally Edmonds, Theonest K. Mutabingwa, Malaria in pregnancy. British Journal of Obstetrics and Gynaecology. ,vol. 112, pp. 1189- 1195 ,(2005) , 10.1111/J.1471-0528.2005.00714.X
Elizabeth A. Ashley, Kasia Stepniewska, Niklas Lindegårdh, Rose McGready, Anna Annerberg, Robert Hutagalung, Thida Singtoroj, Gilvary Hla, Al Brockman, Stephane Proux, Jahser Wilahphaingern, Pratap Singhasivanon, Nicholas J. White, François Nosten, Pharmacokinetic study of artemether-lumefantrine given once daily for the treatment of uncomplicated multidrug-resistant falciparum malaria. Tropical Medicine & International Health. ,vol. 12, pp. 201- 208 ,(2007) , 10.1111/J.1365-3156.2006.01785.X
George O Adjei, Jorgen AL Kurtzhals, Onike P Rodrigues, Michael Alifrangis, Lotte CG Hoegberg, Emmanuel D Kitcher, Ebenezer V Badoe, Roberta Lamptey, Bamenla Q Goka, Amodiaquine-artesunate vs artemether-lumefantrine for uncomplicated malaria in Ghanaian children: a randomized efficacy and safety trial with one year follow-up. Malaria Journal. ,vol. 7, pp. 127- 127 ,(2008) , 10.1186/1475-2875-7-127
Jean Ndiaye, Milijaona Randrianarivelojosia, Issaka Sagara, Philippe Brasseur, Ibrahima Ndiaye, Babacar Faye, Laurence Randrianasolo, Arsène Ratsimbasoa, Doris Forlemu, Vicky Moor, Aminata Traore, Yahia Dicko, Niawanlou Dara, Valérie Lameyre, Mouctar Diallo, Abdoulaye Djimde, Albert Same-Ekobo, Oumar Gaye, Randomized, multicentre assessment of the efficacy and safety of ASAQ – a fixed-dose artesunate-amodiaquine combination therapy in the treatment of uncomplicated Plasmodium falciparum malaria Malaria Journal. ,vol. 8, pp. 125- 125 ,(2009) , 10.1186/1475-2875-8-125
Steffen Borrmann, William M Sallas, Sonia Machevo, Raquel González, Anders Björkman, Andreas Mårtensson, Mary Hamel, Elizabeth Juma, Judy Peshu, Bernhards Ogutu, Abdoulaye Djimdé, Umberto D’Alessandro, Anne‐Claire Marrast, Gilbert Lefèvre, Steven E Kern, None, The effect of food consumption on lumefantrine bioavailability in African children receiving artemether–lumefantrine crushed or dispersible tablets (Coartem®) for acute uncomplicated Plasmodium falciparum malaria Tropical Medicine & International Health. ,vol. 15, pp. 434- 441 ,(2010) , 10.1111/J.1365-3156.2010.02477.X
Harin A. Karunajeewa, Ivo Mueller, Michele Senn, Enmoore Lin, Irwin Law, P. Servina Gomorrai, Olive Oa, Suzanne Griffin, Kaye Kotab, Penias Suano, Nandao Tarongka, Alice Ura, Dulcie Lautu, Madhu Page-Sharp, Rina Wong, Sam Salman, Peter Siba, Kenneth F. Ilett, Timothy M.E. Davis, A Trial of Combination Antimalarial Therapies in Children from Papua New Guinea The New England Journal of Medicine. ,vol. 359, pp. 2545- 2557 ,(2008) , 10.1056/NEJMOA0804915
Bernhards Ogutu, Alfred B Tiono, Michael Makanga, Zulfiqarali Premji, Adama Dodji Gbadoé, David Ubben, Anne Claire Marrast, Oumar Gaye, None, Treatment of asymptomatic carriers with artemether-lumefantrine: an opportunity to reduce the burden of malaria? Malaria Journal. ,vol. 9, pp. 30- 30 ,(2010) , 10.1186/1475-2875-9-30
Babacar Faye, André Touré Offianan, Jean Louis Ndiaye, Roger Clement Tine, Walatchin Touré, Kali Djoman, Khadime Sylla, Paulette Suzanne Ndiaye, Louis Penali, Oumar Gaye, Efficacy and tolerability of artesunate-amodiaquine (Camoquin plus®) versus artemether-lumefantrine (Coartem®) against uncomplicated Plasmodium falciparum malaria: multisite trial in Senegal and Ivory Coast Tropical Medicine & International Health. ,vol. 15, pp. 608- 613 ,(2010) , 10.1111/J.1365-3156.2010.02487.X
Ian M. Hastings, William M. Watkins, Nicholas J. White, The evolution of drug-resistant malaria : the role of drug elimination half-life Philosophical Transactions of the Royal Society B. ,vol. 357, pp. 505- 519 ,(2002) , 10.1098/RSTB.2001.1036