Biobehavioral, Immune, and Health Benefits following Recurrence for Psychological Intervention Participants

摘要: Purpose: A clinical trial was designed to test the hypothesis that a psychological intervention could reduce risk of cancer recurrence. Newly diagnosed regional breast patients (n = 227) were randomized intervention-with-assessment or assessment-only arm. The had positive psychological, social, immune, and health benefits, after median 11 years arm found have reduced recurrence (hazard ratio, 0.55; P =0 .034). In follow-up, we hypothesized might also show longer survival If observed, then would examine potential biobehavioral mechanisms. Experimental Design: All followed; 62 recurred. Survival analyses included all 62. Upon diagnosis, those available for further study accrued 41, 23 18 assessment). For adherence, health, immune (natural killer cell cytotoxicity, T-cell proliferation) data collected at diagnosis 4, 8, 12 months later. Results: Intent-to-treat analysis revealed death following 0.41; 0.014). Mixed-effects follow-up with showed responded significant distress but thereafter only improved (P values < 0.023). Immune indices significantly higher 0.017). Conclusions: Hazards augment previous findings in showing Follow-up advantages contribute our understanding how achieved. Clin Cancer Res; 16(12); 3270–8. ©2010 AACR.